08/9/2021 News Interesting scientific research on 2-(4-Bromobutoxy)tetrahydro-2H-pyran

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There are several literature methods for conversion of 14C precursors into [14C]-acetylenes, and a number of these involve elaboration of [14C]-aldehydes into a terminal acetylenes. One method that involves mild conditions, and in our experience is high yielding and tolerant of a range of functional groups uses the Ohira-Bestmann reagent to effect this transformation. This document briefly describes some of the different methods that have been used for the preparation of [ 14C]-acetylenes and discusses two worked examples, the synthesis of [5-14C]-hex-5-ynoic acid and [benzene-(U)-14C]-7- methoxybenzofuran, both of which involve Ohira-Bestmann chemistry being used for the preparation of terminal [14C]-acetylenes. Copyright

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics