Extended knowledge of 16400-32-1

Here is just a brief introduction to this compound(16400-32-1)Synthetic Route of C5H7Br, more information about the compound(1-Bromo-2-pentyne) is in the article, you can click the link below.

Hock, Katharina J.; Knorrscheidt, Anja; Hommelsheim, Rene; Ho, Junming; Weissenborn, Martin J.; Koenigs, Rene M. published the article 《Tryptamine Synthesis by Iron Porphyrin Catalyzed C-H Functionalization of Indoles with Diazoacetonitrile》. Keywords: tryptamine preparation; indole preparation; diazoacetonitrile indole preparation CH functionalization iron porphyrin catalyst; C−H functionalization; biocatalysis; diazoalkanes; indoles; iron.They researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).Synthetic Route of C5H7Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:16400-32-1) here.

The development of iron porphyrin catalyzed reactions of diazoacetonitrile with N-heterocycles I (R = Me, Ph, thiophen-3-yl, etc.; R1 = CH, N; R2 = H, 2-Me, 5-methoxy, etc.) yielding important precursors of tryptamines II, along with exptl. mechanistic studies and proof-of-concept studies of an enzymic process with YfeX enzyme was described. By using readily available FeTPPCl, the highly efficient C-H functionalization of indole and indazole heterocycles is achieved. These transformations feature mild reaction conditions and excellent yields with broad functional group tolerance, and can be conducted on gram scale, thus providing a unique streamlined access to tryptamines.

Here is just a brief introduction to this compound(16400-32-1)Synthetic Route of C5H7Br, more information about the compound(1-Bromo-2-pentyne) is in the article, you can click the link below.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics