The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ) is researched.Application of 82954-65-2.Angrick, Michael; Rewicki, Dieter published the article 《Reactions of sugars and related polyfunctional compounds with amino acids. 2. N-Acylation of 3-amino-1,2-propanediol with amino acids》 about this compound( cas:82954-65-2 ) in Liebigs Annalen der Chemie. Keywords: acylation aminopropanediol amino acid; propanediol amino acylation. Let’s learn more about this compound (cas:82954-65-2).
Racemic H2NCH2CH(OH)CH2OH was N-acylated with Z-X-OH (Z = PhCH2O2C; X = Ala, Phe, Val, Leu) by 1,1′-carbonyldiimidazole in THF to give Z-X-NHCH2CH(OH)CH2OH (II). In some cases (e.g., X = Ala), one of the 2 diastereoisomers of II spontaneously formed a precipitate, which can be separated The S,S-configuration of II (X = Ala) was established by N-acylating (S)-(aminomethyl)dioxolane (S)-III (R = H) with Z-Ala-OH and cleaving the resulting (S)-III (R = Z-Ala) to give (S,S)-II (X = Ala).
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics