So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lee, Sunkyung; Yi, Kyu Yang; Kim, Soo-Kyung; Suh, Jeehee; Kim, Nak Jeong; Yoo, Sung-Eun; Lee, Byung Ho; Seo, Ho Won; Kim, Sun-Ok; Lim, Hong researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Recommanded Product: Ethyl indoline-2-carboxylate.They published the article 《Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: benzopyranyl indoline and indole analogues》 about this compound( cas:50501-07-0 ) in European Journal of Medicinal Chemistry. Keywords: benzopyranyl indoline indole analog preparation cardioprotective activity; antiischemic ATP sensitive potassium channel opener benzopyranyl indoline; structure activity relationship benzopyranyl indoline indole analog; conformation benzopyranyl indoline indole analog crystal structure. We’ll tell you more about this compound (cas:50501-07-0).
This paper describes the design, syntheses, and biol. evaluations of novel ATP-sensitive potassium channel (KATP) openers, benzopyranyl indoline and indole derivatives Among those, two enantiomers of indoline-2-carboxylic Et esters (14, 18) showed the best cardioprotective activities both in vitro and in vivo, while their vasorelaxation potencies were very low (concentration for 50% inhibition of vasorelaxation >30 μM). The cardioprotective effect of 14 was completely reversed by 5-hydroxydecanoate, a selective mitochondrial KATP blocker, indicating its provable protective mechanism through the mitochondrial KATP opening. In addition, we performed conformational analyses using 2D-NMR, X-ray crystallog. and mol. modeling to study the structure-activity relationships in this series of compounds
In some applications, this compound(50501-07-0)Recommanded Product: Ethyl indoline-2-carboxylate is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics