The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bis(4-chlorophenyl)methyl)piperazine(SMILESS: ClC1=CC=C(C=C1)C(N2CCNCC2)C3=CC=C(Cl)C=C3,cas:27469-61-0) is researched.Recommanded Product: 58081-05-3. The article 《Synthesis and hypocholesterolemic activity of some N-diphenylmethylpiperazine derivatives》 in relation to this compound, is published in Archiv der Pharmazie (Weinheim, Germany). Let’s take a look at the latest research on this compound (cas:27469-61-0).
The synthesis and preliminary assays as hypocholesterolemic agents of five N-phenylmethylpiperazines I [ R = PhCC, 2-(2-thienyl)ethynyl, 2-(2-thienylvinyl); R1 = H, Cl] are described. Thus, 2-thienylacetylene was treated with 1-benphydrylpiperazine and HCHO to give 91% I (R = PhCC, R1 = Cl). The evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. The di-p-chloro substituted compounds showed higher activity than their corresponding dechlorinated analogs.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics