Extended knowledge of 27469-61-0

There is still a lot of research devoted to this compound(SMILES:ClC1=CC=C(C=C1)C(N2CCNCC2)C3=CC=C(Cl)C=C3)HPLC of Formula: 27469-61-0, and with the development of science, more effects of this compound(27469-61-0) can be discovered.

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bis(4-chlorophenyl)methyl)piperazine(SMILESS: ClC1=CC=C(C=C1)C(N2CCNCC2)C3=CC=C(Cl)C=C3,cas:27469-61-0) is researched.HPLC of Formula: 1452-77-3. The article 《Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:27469-61-0).

The preparation and in vitro aromatase-inhibitory activity of a wide variety of heterocyclic diphenylmethane derivatives, e.g., (p-ClC4H4)2CRR1 (R = imidazolyl, pyridyl, pyrimidyl, etc.; R1 = H, HO, 1-imidazolyl), are described. Thus (p-ClC4H4)2CHCl was treated with imidazole in DMF containing NaH to give 1-[bis(p-chlorophenyl)methyl]imidazole. The choice of the 2 diaryl-bearing moieties as a vehicle for evaluating the heterocycles was made by comparing a series of imidazole- and pyridine-derived compounds with similar pyrimidine compounds reported previously. A structural model for the most active compounds is also presented. The activity of a related series of compounds containing 2 heterocyclic moieties was consistent with the model. Many of the compounds evaluated, including representatives of the pyridine, imidazole, pyrimidine, pyrazole, triazole, thiazole, and isothiazole classes, exhibit EC50 potencies for aromatase inhibition at low nanomolar levels. These compounds are at least as potent as other nonsteroidal aromatase inhibitors reported previously.

There is still a lot of research devoted to this compound(SMILES:ClC1=CC=C(C=C1)C(N2CCNCC2)C3=CC=C(Cl)C=C3)HPLC of Formula: 27469-61-0, and with the development of science, more effects of this compound(27469-61-0) can be discovered.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics