Safety of 2-Bromo-5-methylpyrazine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Bromo-5-methylpyrazine, is researched, Molecular C5H5BrN2, CAS is 98006-90-7, about Design of potent and selective GPR119 agonists for type II diabetes. Author is Szewczyk, Jason W.; Acton, John; Adams, Alan D.; Chicchi, Gary; Freeman, Stanley; Howard, Andrew D.; Huang, Yong; Li, Cai; Meinke, Peter T.; Mosely, Ralph; Murphy, Elizabeth; Samuel, Rachel; Santini, Conrad; Yang, Meng; Zhang, Yong; Zhao, Kake; Wood, Harold B..
Screening of the Merck sample collection identified compound 1 (I) as a weakly potent GPR119 agonist (hEC50 = 3600 nM). Dual termini optimization of I led to compound II having improved potency, selectivity, and formulation profile, however, modest phys. properties (PP) hindered its utility. Design of a new core containing a cyclopropyl restriction yielded further PP improvements and when combined with the termini SAR optimizations yielded a potent and highly selective agonist III suitable for further preclin. development.
There is still a lot of research devoted to this compound(SMILES：CC1=CN=C(Br)C=N1)Safety of 2-Bromo-5-methylpyrazine, and with the development of science, more effects of this compound(98006-90-7) can be discovered.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics