So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Fujimoto, Teppei; Becker, Fabian; Ritter, Tobias researched the compound: 2-Chloro-1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-3-ium chloride( cas:1228185-09-8 ).Related Products of 1228185-09-8.They published the article 《PhenoFluor: Practical Synthesis, New Formulation, and Deoxyfluorination of Heteroaromatics》 about this compound( cas:1228185-09-8 ) in Organic Process Research & Development. Keywords: PhenoFluor synthesis formulation toluene solution deoxyfluorination heteroaromatic. We’ll tell you more about this compound (cas:1228185-09-8).
We report a practical synthesis method of the reagent PhenoFluor [N,N’-1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole] on decagram scale, provide a new formulation of PhenoFluor as a toluene solution, which should decrease challenges associated with the moisture sensitivity of the reagent, and expand the substrate scope of deoxyfluorination with PhenoFluor to heteroaromatics Thus, e.g., deoxyfluorination of isoquinolin-5-ol with PhenoFluor and CsF afforded 5-fluoroisoquinoline in 93% yield.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics