Extracurricular laboratory: Synthetic route of 603130-12-7

There are many compounds similar to this compound(603130-12-7)COA of Formula: C11H21NO4. if you want to know more, you can check out my other articles. I hope it will help you,maybe you’ll find some useful information.

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity, published in 2013-09-26, which mentions a compound: 603130-12-7, mainly applied to pyran tetrahydro Gram pos bacterial topoisomerase inhibitor; DNA gyrase topoisomerase inhibitor tetrahydropyran bicyclic aromatic derivative, COA of Formula: C11H21NO4.

There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the potential to become such drugs because they display potent antibacterial activity and exhibit no target-mediated cross-resistance with fluoroquinolones. Bacterial topoisomerase inhibitors that are built on a tetrahydropyran ring linked to a bicyclic aromatic moiety through a syn-diol linker show potent anti-Gram-pos. activity, covering isolates with clin. relevant resistance phenotypes. For instance, analog I was found to be a dual DNA gyrase-topoisomerase IV inhibitor, with broad antibacterial activity and low propensity for spontaneous resistance development, but suffered from high hERG K+ channel block. On the other hand, analog II displayed lower hERG K+ channel block while retaining potent in vitro antibacterial activity and acceptable frequency for resistance development. Furthermore, analog II showed moderate clearance in rat and promising in vivo efficacy against Staphylococcus aureus in a murine infection model.

There are many compounds similar to this compound(603130-12-7)COA of Formula: C11H21NO4. if you want to know more, you can check out my other articles. I hope it will help you,maybe you’ll find some useful information.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics