The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine(SMILESS: NC[C@@H]1OC(C)(C)OC1,cas:82954-65-2) is researched.Related Products of 18362-64-6. The article 《A flexible route to new spirodioxanes, oxathianes, and morpholines》 in relation to this compound, is published in Tetrahedron. Let’s take a look at the latest research on this compound (cas:82954-65-2).
This work describes a modular efficient route to 10-aza-4-thia-, 10-aza-4-oxa-, and 10-oxa-4-thia-1,7-dioxaspiro[5.5]undecanes. The synthetic pathway relies upon the iterative nucleophilic substitution of 1,3-dichloropropan-2-one O-benzyloxime by solketal derivatives The oxime key-intermediates, submitted to an acidic deprotection-spiroacetalization process, afforded these original spiroketal compounds in three steps, few purifications, and very good yields.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics