The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromo-5-methylpyrazine( cas:98006-90-7 ) is researched.Category: tetrahydropyran.Chen, Xiangyang; Pierce, Betsy; Naing, Win; Grapperhaus, Margaret L.; Phillion, Dennis P. published the article 《Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist》 about this compound( cas:98006-90-7 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: P2X7 receptor antagonist cyclohexyl pyrimidinylbenzamide preparation SAR. Let’s learn more about this compound (cas:98006-90-7).
Focused SAR studies were carried out around 5-heteroaryl and 1-amide portions of the 2-chlorobenzamide scaffold, resulting in the discovery of a potent, metabolically stable and centrally penetrable antagonist against P2X7 receptor.
From this literature《Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist》,we know some information about this compound(98006-90-7)Category: tetrahydropyran, but this is not all information, there are many literatures related to this compound(98006-90-7).
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics