So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Laher, Romain; Gentilini, Emilie; Marin, Christophe; Michelet, Veronique researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).Synthetic Route of C5H7Br.They published the article 《Oxygen-Tethered 1,6-Enynes and [4.1.0]-Bicyclic Ether Skeletons as Hedonic Materials for the Fragrance Industry》 about this compound( cas:16400-32-1 ) in Synthesis. Keywords: bicyclic ether preparation olfactive property; alkenyne cycloisomerization nitrogen heterocyclic carbene gold complex catalyst. We’ll tell you more about this compound (cas:16400-32-1).
The synthesis of original structures for the fragrance industry bearing bicyclic scaffolds is described. To the best of authors’ knowledge, these structures are not found in the fragrance industry, neither from natural nor synthetic pathways. NHC-gold-type catalysts showed excellent activities leading to light bicyclic enol ethers. Several bicyclic adducts I (X = O, S; R1 = H, Me, Bn, etc.; R2 = H, Me, Ph; R3 = H, Me; -R2R3- = -(CH2)5-; R4 = n-Pr, Ph, 4-F3CC6H4, etc.; R5 = H, n-Pr) were prepared in good to excellent yields (18-99%). Evaluation of NHC-Au complexes allowed to reach a TOF of 300 h-1. The evaluation for the organoleptic properties of [4.1.0]-bicyclic ethers were compared with the unprecedented properties of the 1,6-enyne precursors. Evaluations of starting materials showed a great interest in these structures with various olfactory facets. In this study, the similarity and differences between starting ethers and their cycloisomerized bicyclic counterparts are depicted.
Here is just a brief introduction to this compound(16400-32-1)Synthetic Route of C5H7Br, more information about the compound(1-Bromo-2-pentyne) is in the article, you can click the link below.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics