In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Metal-Free, Base-Promoted, Tandem Pericyclic Reaction: A One-Pot Approach for Cycloheptane-Annelated Chromones from γ-Alkynyl-1,3-Diketones, published in 2022-01-18, which mentions a compound: 16400-32-1, mainly applied to cycloheptachromone preparation; alkynyl diketone methoxyphenyl preparation intramol pericyclization, Category: tetrahydropyran.
A microwave-assisted, base-promoted tandem cyclization reaction strategy has been developed for the synthesis of cyclohepta[b]chromones I (R1 = H, Me, MeO, Cl, Ph, 4-MeOC6H4; R2 = H, Me, MeO; R3 = H; R2R3 = CH:CHCH:CH; R4 = H, Me, Et; R5 = H; R6 = H, Me, n-Pr, cyclopropyl, n-hexyl) and spiro cyclohepta[b]chromones I [R1 = H, Cl, Me, 4-MeC6H4O; R2 = H, Me, MeO; R3 = H; R4R5 = (CH2)3, (CH2)4, (CH2)5; R6 = H, Me]. Readily accessible γ-alkynyl-1,3-diketones II (X = MeO, Cl, Br, I) underwent intramol. cyclization and 7-endo-trig carbocyclization to afford various cycloheptane-annelated chromones I in one-pot reactions. This metal-free protocol also led to the generation of polycyclic ring with a new C-C bond and a new C-O bond.
Compound(16400-32-1)Category: tetrahydropyran received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-Bromo-2-pentyne), if you are interested, you can check out my other related articles.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics