Okamoto, Akimitsu; Nakamura, Takashi; Yoshida, Kohzo; Nakatani, Kazuhiko; Saito, Isao published the article 《Site-Selective DNA Alkylation of GG Steps by Naphthaldiimide Derivatives Possessing Enantiomeric Epoxide》. Keywords: DNA alkylation guanine naphthaldiimide epoxide; enantiomer epoxide naphthaldiimide epoxide DNA.They researched the compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ).Electric Literature of C6H13NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:82954-65-2) here.
We have synthesized an enantiomeric pair of novel DNA alkylating agents consisting of a naphthaldiimide intercalator and a chiral epoxy side chain. These naphthaldiimide derivatives have high DNA binding affinity and selectively alkylate 5’G of the GG steps for (S)-epoxide and 3’G for (R)-epoxide.
Compound(82954-65-2)Electric Literature of C6H13NO2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine), if you are interested, you can check out my other related articles.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics