The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromo-5-methylpyrazine( cas:98006-90-7 ) is researched.Category: tetrahydropyran.Hesp, Kevin D.; Fernando, Dilinie P.; Jiao, Wenhua; Londregan, Allyn T. published the article 《Expedient Synthesis of α-Heteroaryl Piperidines Using a Pd-Catalyzed Suzuki Cross-Coupling-Reduction Sequence》 about this compound( cas:98006-90-7 ) in Organic Letters. Keywords: piperidine heteroaryl preparation; heteroaryl bromide Suzuki boronate ester reduction palladium catalyst. Let’s learn more about this compound (cas:98006-90-7).
A method for the modular synthesis of α-heteroaryl piperidines is reported. The two-step procedure consists of an initial Pd-catalyzed Suzuki cross-coupling of the heteroaryl bromide with a boronate ester derived from N-Boc-piperidone, followed by subsequent tetrahydropyridine reduction Using this method, α-heteroaryl piperidine products featuring a broad range of pharmaceutically relevant azine and diazine substitutions have been prepared
In addition to the literature in the link below, there is a lot of literature about this compound(2-Bromo-5-methylpyrazine)Category: tetrahydropyran, illustrating the importance and wide applicability of this compound(98006-90-7).
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics