Chen, Jiahua; Hayashi, Tamio published the article 《Asymmetric Synthesis of Alkylzincs by Rhodium-Catalyzed Enantioselective Arylative Cyclization of 1,6-Enynes with Arylzincs》. Keywords: asym synthesis alkylzinc rhodium catalyzed enantioselective arylative cyclization enyne; asymmetric carbometalation; chiral diene ligand; enantioenriched alkylzinc; rhodium catalyst.They researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).HPLC of Formula: 16400-32-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:16400-32-1) here.
A chiral diene-rhodium complex was found to catalyze the reaction of 1,6-enynes with ArZnCl to give high yields of 2-(alkylidene)cyclopentylmethylzincs with high enantioselectivity (95-99% ee). The enantioenriched alkylzincs were readily converted in a one-pot approach into a wide variety of functionalized products by taking advantage of their unique reactivity. The catalytic cycle involves arylrhodation of alkyne, intramol. alkenylrhodation of alkene, and transmetalation of the alkyl-rhodium intermediate into alkylzinc. Thus, e.g., treatment of enyne I with 4-MeOC6H4ZnCl and ZnCl2 in presence of chiral Rh complex afforded regioisomers II/III (88%, 20/1) after DOAc quenching, consistent with alkylzinc and arylzinc intermediates.
In addition to the literature in the link below, there is a lot of literature about this compound(1-Bromo-2-pentyne)HPLC of Formula: 16400-32-1, illustrating the importance and wide applicability of this compound(16400-32-1).
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics