Reference of 1-Bromo-2-pentyne. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about An Expeditious Route for the Synthesis of Oxazepine Triazolo-β-Lactams through Intramolecular Metal-Free [3+2] Azide-Alkyne Cycloaddition. Author is Yadav, Ram N.; Chandra, Sunena; Paniagua, Armando; Hossain, Firoj Md.; Banik, Bimal Krishna.
A copper-free intramol. azide-alkyne cycloaddition reaction of 4-hydroxymethyl-β-lactam with sodium azide was described. The present approach involves the incorporation of an alkyne moiety through O-alkynylation of 3-hydroxy β-lactam with various propargylic halides. The generality of the method was demonstrated by treating the corresponding tosylates or mesylates of the hydroxymethyl functionality of a variety of β-lactam-tethered terminal and internal alkynes with sodium azide in a one-pot three-step reaction to furnish novel oxazepane-β-lactam fused triazole scaffolds of diverse interest in good yield.
In addition to the literature in the link below, there is a lot of literature about this compound(1-Bromo-2-pentyne)Reference of 1-Bromo-2-pentyne, illustrating the importance and wide applicability of this compound(16400-32-1).
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics