Share an extended knowledge of a compound : 97739-46-3

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Name: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Synthesis of β2,2-Amino esters via Rh-Catalysed Regioselective Hydroaminomethylation. Author is Cunillera, Anton; Ruiz, Aurora; Godard, Cyril.

The synthesis of β2,2-amino esters was successfully achieved via Rh-catalyzed regioselective hydroaminomethylation of Me methacrylate with secondary amines using the neutral precursor Rh(acac)(CO)2. In this process, the presence of mol. sieves was crucial in order to access the final amino ester. For the synthesis of products containing aniline derivatives, the use of the cationic precursor [Rh(COD)2]BF4 and MeCgPPh phosphine I as ligand was necessary in a mixture of toluene/DCE as solvent. Effects of the steric and electronic properties of the amines were observed Interestingly, the poisoning effect of CO in the hydrogenation of the imine intermediate was observed when benzyl amine was used.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Discovery of 97739-46-3

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor, the main research direction is tumor BCLXL BCL2 apoptosis A1155463 structure based drug design.COA of Formula: C16H21O3P.

Herein we describe the discovery of A-1331852(I), a first-in-class orally active BCL-XL inhibitor that selectively and potently induces apoptosis in BCL-XL dependent tumor cells. This mol. was generated by re-engineering our previously reported BCL-XL inhibitor A-1155463 using structure-based drug design. Key design elements included rigidification of the A-1155463 pharmacophore and introduction of sp3-rich moieties capable of generating highly productive interactions within the key P4 pocket of BCL-XL. A-1331852 has since been used as a critical tool mol. for further exploring BCL-2 family protein biol., while also representing an attractive entry into a drug discovery program.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Some scientific research about 97739-46-3

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of Dibenzo[b,f][1,4]oxazepin-11(10H)-ones via Intramolecular Cyclocarbonylation Reactions Using PdI2/Cytop 292 as the Catalytic System, published in 2010-09-17, which mentions a compound: 97739-46-3, mainly applied to dibenzooxazepinone preparation; phenoxyaniline intramol cyclocarbonylation palladium tetramethylphenyltrioxaphospha adamantane catalyst, Electric Literature of C16H21O3P.

The intramol. cyclocarbonylation of substituted 2-(2-iodophenoxy)anilines, e.g. I, was catalyzed by PdI2 and 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phospha-adamantane (Cytop 292) in an efficient manner. A series of substituted dibenzo[b,f][1,4]oxazepin-11(10H)-ones, e.g. II, were prepared in good yields under mild reaction conditions.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Continuously updated synthesis method about 50501-07-0

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Jing-Jiang; Guo, Fu-Hu; Cui, Fu-Jun; Zhu, Ji-Hua; Liu, Xiao-Yu; Ullah, Arif; Wang, Xi-Cun; Quan, Zheng-Jun researched the compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ).Reference of Ethyl indoline-2-carboxylate.They published the article 《A biomass-derived N-doped porous carbon catalyst for the aerobic dehydrogenation of nitrogen heterocycles》 about this compound( cas:50501-07-0 ) in New Journal of Chemistry. Keywords: biomass carbon catalyst aerobic dehydrogenation nitrogen heterocycle. We’ll tell you more about this compound (cas:50501-07-0).

N-doped porous carbon (NC) was synthesized from sugar cane bagasse, which is a sustainable and widely available biomass waste. The preferred NC sample had a well-developed porous structure, a graphene-like surface morphol. and different N species. More importantly, the heterogeneous carbocatalyst exhibited superior catalytic performance in the aerobic dehydrogenation of various heterocyclic nitrogen compounds (49 examples, up to 96% yield), similar to that of C3N4 and GO. Characterization by TEM, BET and XPS accompanied by the EPR anal. revealed that the enhanced catalytic properties of NC came from its high activation ability for both O2 and heterocyclic nitrogen, attributed to the porous structure and pyridinic N (N-6) species, resp.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The Best Chemistry compound: 27469-61-0

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and quantitative structure-activity relationships of antibacterial 1-(substituted benzhydryl)-4-(5-nitro-2-furfurylideneamino)piperazines, published in 1978-07-31, which mentions a compound: 27469-61-0, mainly applied to piperazine benzhydryl nitrofurfurylideneamino; bactericide benzhydrylnitrofurylideneaminopiperazine; structure activity bactericide piperazine, Safety of 1-(Bis(4-chlorophenyl)methyl)piperazine.

Twelve title compounds I (R = H, 4-Cl, 3-Me, 3,4-Cl2, etc., R1 = H, Cl, Me) were prepared by treating the corresponding benzhydryl chloride with piperazine followed by nitrosation, reduction, and condensation with 5-nitro-2-furancarboxaldehyde. I were examined for in vitro antimicrobial activity. The compounds were active against Bacillus cereus 7, Bacillus megaterium 122, Bacillus subtilis 104, Clostridium perfringens 13, and the tetracycline-resistant Clostridium perfringens 37. Regression analyses on the antibacterial activity data based on the Hansch approach, using π, π2, and σ parameters, yielded several statistically significant correlation equations. 1-Benzhydryl-4-(5-nitro-2-furfurylideneamino)piperazine stopped the protein and DNA syntheses in C. perfringens 13, as indicated by precipitable radioactivity. The compound, however, showed no effect on the cell wall synthesis in the bacteria.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

What I Wish Everyone Knew About 27469-61-0

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 27469-61-0, is researched, SMILESS is ClC1=CC=C(C=C1)C(N2CCNCC2)C3=CC=C(Cl)C=C3, Molecular C17H18Cl2N2Journal, Comparative Study, Article, Journal of Medicinal Chemistry called Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups, Author is Jones, C. David; Winter, Mark A.; Hirsch, Kenneth S.; Stamm, Nancy; Taylor, Harold M.; Holden, Howard E.; Davenport, James D.; Krumkalns, Eriks V.; Suhr, Robert G., the main research direction is heterocycle nitrogen diphenylmethyl preparation aromatase inhibition; imidazole diphenylmethyl preparation aromatase inhibitor; pyridine diphenylmethyl preparation aromatase inhibitor.Recommanded Product: 27469-61-0.

The preparation and in vitro aromatase-inhibitory activity of a wide variety of heterocyclic diphenylmethane derivatives, e.g., (p-ClC4H4)2CRR1 (R = imidazolyl, pyridyl, pyrimidyl, etc.; R1 = H, HO, 1-imidazolyl), are described. Thus (p-ClC4H4)2CHCl was treated with imidazole in DMF containing NaH to give 1-[bis(p-chlorophenyl)methyl]imidazole. The choice of the 2 diaryl-bearing moieties as a vehicle for evaluating the heterocycles was made by comparing a series of imidazole- and pyridine-derived compounds with similar pyrimidine compounds reported previously. A structural model for the most active compounds is also presented. The activity of a related series of compounds containing 2 heterocyclic moieties was consistent with the model. Many of the compounds evaluated, including representatives of the pyridine, imidazole, pyrimidine, pyrazole, triazole, thiazole, and isothiazole classes, exhibit EC50 potencies for aromatase inhibition at low nanomolar levels. These compounds are at least as potent as other nonsteroidal aromatase inhibitors reported previously.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Little discovery in the laboratory: a new route for 82954-65-2

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine, is researched, Molecular C6H13NO2, CAS is 82954-65-2, about Self-assembly of small-molecule fumaramides allows transmembrane chloride channel formation, the main research direction is selfassembly fumaramide transmembrane chloride channel.Name: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.

This study reports the formation of self-assembled transmembrane anion channels by small-mol. fumaramides. Such artificial ion channel formation was confirmed by ion transport across liposomes and by planar bilayer conductance measurements. The geometry-optimized model of the channel and Cl- ion selectivity within the channel lumen was also illustrated.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Application of 1228185-09-8

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Fujimoto, Teppei; Becker, Fabian; Ritter, Tobias published an article about the compound: 2-Chloro-1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-3-ium chloride( cas:1228185-09-8,SMILESS:CC(C1=C([N+]2=C(Cl)N(C3=C(C(C)C)C=CC=C3C(C)C)C=C2)C(C(C)C)=CC=C1)C.[Cl-] ).Recommanded Product: 1228185-09-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1228185-09-8) through the article.

We report a practical synthesis method of the reagent PhenoFluor [N,N’-1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole] on decagram scale, provide a new formulation of PhenoFluor as a toluene solution, which should decrease challenges associated with the moisture sensitivity of the reagent, and expand the substrate scope of deoxyfluorination with PhenoFluor to heteroaromatics Thus, e.g., deoxyfluorination of isoquinolin-5-ol with PhenoFluor and CsF afforded 5-fluoroisoquinoline in 93% yield.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromo-2-pentyne( cas:16400-32-1 ) is researched.SDS of cas: 16400-32-1.Caciolla, Jessica; Spinello, Angelo; Martini, Silvia; Bisi, Alessandra; Zaffaroni, Nadia; Gobbi, Silvia; Magistrato, Alessandra published the article 《Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors》 about this compound( cas:16400-32-1 ) in ACS Medicinal Chemistry Letters. Keywords: breast cancer aromatase inhibitors mol dynamics cytochromes P450. Let’s learn more about this compound (cas:16400-32-1).

Breast cancer (BC) is the most diffused cancer type in women and the second leading cause of death among the female population. Effective strategies to fight estrogen responsive (ER+) BC, which represents 70% of all BC cases, rely on estrogen deprivation, via the inhibition of the aromatase enzyme, or the modulation of its cognate estrogen receptor. Current clin. therapies significantly increased patient survival time. Nevertheless, the onset of resistance in metastatic BC patients undergoing prolonged treatments is becoming a current clin. challenge, urgently demanding to devise innovative strategies. In this context, here we designed, synthesized, and performed in vitro inhibitory tests on the aromatase enzyme and distinct ER+/ER- BC cell line types of novel azole bridged xanthones. These compounds are active in the low μM range and behave as dual-mode inhibitors, targeting both the orthosteric and the allosteric sites of the enzyme placed along one access channel. Classical and quantum-classical mol. dynamics simulations of the new compounds, as compared with selected steroidal and nonsteroidal inhibitors, provide a rationale to the observed inhibitory potency and supply the guidelines to boost the activity of inhibitors able to exploit coordination to iron and occupation of the access channel to modulate estrogen production

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Tetrahydropyran – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ) is researched.Safety of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.Danieli, Elisa; Trabocchi, Andrea; Menchi, Gloria; Guarna, Antonio published the article 《Synthesis of glycidol- and sugar-derived bicyclic β- and γ/δ-amino acids for peptidomimetic design》 about this compound( cas:82954-65-2 ) in European Journal of Organic Chemistry. Keywords: amino acid bicyclic glycidol sugar preparation; peptidomimetic bicyclic amino acid solid phase synthesis. Let’s learn more about this compound (cas:82954-65-2).

Constrained bicyclic β- and γ/δ-amino acids I (R = H or CH2OBn; Fmoc = fluorenylmethoxycarbonyl, Bn = benzyl) and II were developed using glycidol and sugar derivatives The synthetic strategies involved epoxide ring opening of a glycidol derivative, and subsequent coupling with sugar-derived amines, leading to di- or trisubstituted bicyclic scaffolds after cyclization with trifluoroacetic acid. Achievement of β- or γ/δ-amino acids was accomplished by changing the protecting group strategy of the starting materials. Compatibility of the scaffold with solid-phase peptide synthesis was assessed by preparing model peptidomimetics using acid- and base-labile resins, thus giving a new tool for peptidomimetic design.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics