The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine( cas:82954-65-2 ) is researched.Safety of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.Danieli, Elisa; Trabocchi, Andrea; Menchi, Gloria; Guarna, Antonio published the article 《Synthesis of glycidol- and sugar-derived bicyclic β- and γ/δ-amino acids for peptidomimetic design》 about this compound( cas:82954-65-2 ) in European Journal of Organic Chemistry. Keywords: amino acid bicyclic glycidol sugar preparation; peptidomimetic bicyclic amino acid solid phase synthesis. Let’s learn more about this compound (cas:82954-65-2).
Constrained bicyclic β- and γ/δ-amino acids I (R = H or CH2OBn; Fmoc = fluorenylmethoxycarbonyl, Bn = benzyl) and II were developed using glycidol and sugar derivatives The synthetic strategies involved epoxide ring opening of a glycidol derivative, and subsequent coupling with sugar-derived amines, leading to di- or trisubstituted bicyclic scaffolds after cyclization with trifluoroacetic acid. Achievement of β- or γ/δ-amino acids was accomplished by changing the protecting group strategy of the starting materials. Compatibility of the scaffold with solid-phase peptide synthesis was assessed by preparing model peptidomimetics using acid- and base-labile resins, thus giving a new tool for peptidomimetic design.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics