Name: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Synthesis of β2,2-Amino esters via Rh-Catalysed Regioselective Hydroaminomethylation. Author is Cunillera, Anton; Ruiz, Aurora; Godard, Cyril.
The synthesis of β2,2-amino esters was successfully achieved via Rh-catalyzed regioselective hydroaminomethylation of Me methacrylate with secondary amines using the neutral precursor Rh(acac)(CO)2. In this process, the presence of mol. sieves was crucial in order to access the final amino ester. For the synthesis of products containing aniline derivatives, the use of the cationic precursor [Rh(COD)2]BF4 and MeCgPPh phosphine I as ligand was necessary in a mixture of toluene/DCE as solvent. Effects of the steric and electronic properties of the amines were observed Interestingly, the poisoning effect of CO in the hydrogenation of the imine intermediate was observed when benzyl amine was used.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics