Alivert, Antonio; Canals, Francesc; Bonet, Juan Julio; Gomez-Parra, Vicente; Sanchez-Alonso, Felix published the article 《Synthesis and hypocholesterolemic activity of some N-diphenylmethylpiperazine derivatives》. Keywords: diphenylmethylpiperazine preparation hypocholesterolemic; piperazine diphenylmethyl preparation hypocholesterolemic.They researched the compound: 1-(Bis(4-chlorophenyl)methyl)piperazine( cas:27469-61-0 ).Formula: C17H18Cl2N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:27469-61-0) here.
The synthesis and preliminary assays as hypocholesterolemic agents of five N-phenylmethylpiperazines I [ R = PhCC, 2-(2-thienyl)ethynyl, 2-(2-thienylvinyl); R1 = H, Cl] are described. Thus, 2-thienylacetylene was treated with 1-benphydrylpiperazine and HCHO to give 91% I (R = PhCC, R1 = Cl). The evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. The di-p-chloro substituted compounds showed higher activity than their corresponding dechlorinated analogs.
As far as I know, this compound(27469-61-0)Formula: C17H18Cl2N2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics