The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromo-2-pentyne( cas:16400-32-1 ) is researched.COA of Formula: C5H7Br.Torres-Garcia, Irene; Lopez-Martinez, Josefa L.; Martinez-Martinez, Raquel; Oltra, J. Enrique; Munoz-Dorado, Manuel; Rodriguez-Garcia, Ignacio; Alvarez-Corral, Miriam published the article 《The half-sandwich titanocene CpTiIIICl2 as efficient system for the preparation of 2,5-dihydrofurans via α-allenols》 about this compound( cas:16400-32-1 ) in Applied Organometallic Chemistry. Keywords: haloalkyne aldehyde titanium catalyst regioselective barbier type reaction; homopropargylic alc preparation; allenol preparation. Let’s learn more about this compound (cas:16400-32-1).
The half-sandwich titanocene reagent CpTiIIICl2, obtained by in-situ reduction of com. CpTiCl3 with manganese, was an excellent system for the Barbier-type reaction between aldehydes and propargylic halides, led to homopropargylic alcs. and α-allenols. An efficient and straightforward methodol. for the conversion of aldehydes into 2,5-dihydrofurans involving a two-step sequence (TiIII addition-AgI cyclization) was presented. The usefulness of the method was proved by the preparation of a Natural Product: a dihydrofuranic labdane, isolated from the leaves of Mikania sp. nov.
As far as I know, this compound(16400-32-1)COA of Formula: C5H7Br can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics