So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Younes, S.; Baziard-Mouysset, G.; de Saqui-Sannes, G.; Stigliani, J. L.; Payard, M.; Bonnafous, R.; Tisne-Versailles, J. researched the compound: 1-(Bis(4-chlorophenyl)methyl)piperazine( cas:27469-61-0 ).Application In Synthesis of 1-(Bis(4-chlorophenyl)methyl)piperazine.They published the article 《Synthesis and pharmacological study of new calcium antagonists, analogs of cinnarizine and flunarizine》 about this compound( cas:27469-61-0 ) in European Journal of Medicinal Chemistry. Keywords: ethyl phosphonate benzhydrylpiperazinyl calcium antagonist preparation; piperazinylmethylbenzyl phosphonate preparation calcium antagonist. We’ll tell you more about this compound (cas:27469-61-0).
Several phosphonic di-Et esters were prepared and their Ca antagonistic activity evaluated in vitro. The di-Et phosphonate group was condensed on substituted [diphenylmethyl], [(2-benzofuranyl)phenylmethyl], [(4-diphenylmethyl-1-piperazinyl) methyl], [4-(4-diphenylmethyl-1-piperazinyl methyl) phenylmethyl], and [4-(3-phenyl-2-propenyl)-1-piperazinyl methyl] groups. Despite the presence of the di-Et phosphonate moiety and the benzhydrylpiperazinyl group, both present in potent Ca antagonist structures, only one of the 19 prepared compounds, i.e. I, exhibited a Ca antagonistic profile.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics