Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Nature Catalysis called SmI2-catalysed cyclization cascades by radical relay, Author is Huang, Huan-Ming; McDouall, Joseph J. W.; Procter, David J., which mentions a compound: 16400-32-1, SMILESS is CCC#CCBr, Molecular C5H7Br, Recommanded Product: 16400-32-1.
Radical cyclization cascades that are catalyzed by SmI2 and exploit a radical relay/electron-catalysis strategy have been developed. The approach negates the need for a super-stoichiometric co-reductant and requires no additives. Complex cyclic products e.g., I, including products of dearomatization, containing up to four contiguous stereocenter are obtained in excellent yield. Mechanistic studies support a single-electron-transfer radical mechanism. This strategy provides a long-awaited solution to the problem of how to avoid the need for stoichiometric amounts of SmI2 and establishes a conceptual platform on which other catalytic radical processes using the ubiquitous reducing agent can be built.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics