Pace, Domenic P.; Robidas, Raphael; Tran, Uyen P. N.; Legault, Claude Y.; Nguyen, Thanh Vinh published the article 《Iodine-Catalyzed Synthesis of Substituted Furans and Pyrans: Reaction Scope and Mechanistic Insights》. Keywords: keto ester unsaturated iodine intramol cyclization catalyst; furan preparation; pyran preparation.They researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).HPLC of Formula: 16400-32-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:16400-32-1) here.
Substituted pyrans and furans are core structures found in a wide variety of natural products and biol. active compounds Herein, we report a practical and mild catalytic method for the synthesis of substituted pyrans and furans using mol. iodine, a simple and inexpensive catalyst. The method described is performed under solvent-free conditions at an ambient temperature and atm., thus offering a facile and practical alternative to currently available reaction protocols. A combination of exptl. studies and d. functional theory calculations revealed interesting mechanistic insights into this seemingly simple reaction.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics