The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Chloro-1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-3-ium chloride, is researched, Molecular C27H36Cl2N2, CAS is 1228185-09-8, about Site-specific deoxyfluorination of small peptides with [18F]fluoride, the main research direction is fluorine labeled peptide synthesis radiotracer PET; peptide tyrosine chemoselective radio deoxyfluorination traceless activating group substitution; solid phase peptide synthesis deoxyfluorination catalyst ruthenium solvent effect; deoxyfluorination; fluorine; peptide labeling; radiochemistry; η6 activation.Category: tetrahydropyran.
Radiolabeled receptor-binding peptides are an important class of positron emission tomog. tracers owing to achievable high binding affinities and their rapid blood clearance. Herein, a method to introduce a 4-[18F]fluoro-phenylalanine residue into peptide sequences is reported, by chemoselective radio-deoxyfluorination of a tyrosine residue using a traceless activating group. The replacement of only one hydrogen atom with [18F]fluoride results in minimal structural perturbation of the peptide, which is desirable in the labeling of tracer candidates.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics