Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 98006-90-7, is researched, SMILESS is CC1=CN=C(Br)C=N1, Molecular C5H5BrN2Journal, Organic Chemistry: An Indian Journal called An efficient and facile synthesis of 2-bromo-5-methylpyrazine, Author is Madhusudhan, G.; Vysabhattar, Raman; Reddy, R. Naveen; Narayana, B. Venkata, the main research direction is pyrazinecarboxylate preparation amidation; pyrazinecarboxamide preparation Hofmann degradation; aminomethylpyrazine preparation diazotization bromination; bromomethylpyrazine preparation; pyrazine bromo methyl preparation.Electric Literature of C5H5BrN2.
A facile and efficient synthesis of 2-bromo-5-methylpyrazine was described. The title compound was obtained by conversion of 5-methylpyrazine-2-carboxylate to the corresponding amide, which on Hofmann degradation gave the resp. amine. This amine on diazotization followed by in-situ bromination produced the targeted 2-bromo-5-methylpyrazine.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics