Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 98006-90-7, is researched, Molecular C5H5BrN2, about Design of potent and selective GPR119 agonists for type II diabetes, the main research direction is GPR119 agonist antidiabetic preparation structure activity.Electric Literature of C5H5BrN2.
Screening of the Merck sample collection identified compound 1 (I) as a weakly potent GPR119 agonist (hEC50 = 3600 nM). Dual termini optimization of I led to compound II having improved potency, selectivity, and formulation profile, however, modest phys. properties (PP) hindered its utility. Design of a new core containing a cyclopropyl restriction yielded further PP improvements and when combined with the termini SAR optimizations yielded a potent and highly selective agonist III suitable for further preclin. development.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics