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Compounds in my other articles are similar to this one(1-(Bis(4-chlorophenyl)methyl)piperazine)Reference of 1-(Bis(4-chlorophenyl)methyl)piperazine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bis(4-chlorophenyl)methyl)piperazine( cas:27469-61-0 ) is researched.Reference of 1-(Bis(4-chlorophenyl)methyl)piperazine.Nishikawa, Yoshinori; Shindo, Tokuhiko; Ishii, Katsumi; Nakamura, Hideo; Kon, Tatsuya; Uno, Hitoshi published the article 《Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides》 about this compound( cas:27469-61-0 ) in Journal of Medicinal Chemistry. Keywords: phenylmethylpiperazinylbutylpyridylacrylamide preparation antiallergic; structure activity phenylmethylpiperazinylbutylpyridylacrylamide antiallergic; pyridylacrylamide diphenylmethylpiperazinylbutyl preparation antiallergic; acrylamide pyridyldiphenylmethylpiperazinebutyl preparation antiallergic. Let’s learn more about this compound (cas:27469-61-0).

A new series of 3-(3-pyridyl)acrylamides, e.g., I (R = H, R1 = 4-F, 4-Cl, 4-OMe, 3-Me, 4-Me, R2 = H, 4-Cl, 4-Me; R = 2-Cl, 2-NHMe, 2-Me, 5-F, 5-Cl, 5-Br, 5-OMe, 5-OH, 6-Cl, 6-OMe, 6-Me, 6-Bu, R1 = R2 = H), and 5-(3-pyridyl)-2,4-pentadienamides, e.g., II (R = H, Me, n = 3,4) were prepared and evaluated for antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compound I (R = R1 = R2 = H) against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, I (R = 6-Me, R1 = R2 = H) (III) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, III showed a better balance of antiallergic properties due to inhibition of chem. mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.

Compounds in my other articles are similar to this one(1-(Bis(4-chlorophenyl)methyl)piperazine)Reference of 1-(Bis(4-chlorophenyl)methyl)piperazine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics