The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromo-2-pentyne( cas:16400-32-1 ) is researched.Safety of 1-Bromo-2-pentyne.Zhao, Wei-Cheng; Wang, Xin; Feng, Juhua; Tian, Ping; He, Zhi-Tao published the article 《Palladium-catalyzed desymmetric [2+2+2] cycloaddition of 1,6-enyne and alkyne》 about this compound( cas:16400-32-1 ) in Tetrahedron. Keywords: fused tricyclic hydronaphthofuran hydronaphthopyrrole preparation stereoselective; internal alkyne enyne desym cycloaddition palladium catalyst. Let’s learn more about this compound (cas:16400-32-1).
A novel and straightforward palladium-catalyzed desym. [2+2+2] cycloaddition reaction of alkyne-tethered cyclohexadienone and internal alkyne is established. Widely existing fused tricyclic hydronaphthofuran and hydronaphthopyrrole frameworks are prepared diastereoselectively in moderate to excellent yields. One-step aromatization process provides a new and facile access to important benzene-containing tricycles from above cycloaddition products.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics