Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 82954-65-2, is researched, SMILESS is NC[C@@H]1OC(C)(C)OC1, Molecular C6H13NO2Journal, Tetrahedron called A flexible route to new spirodioxanes, oxathianes, and morpholines, Author is Goubert, Marlene; Canet, Isabelle; Sinibaldi, Marie-Eve, the main research direction is dichloropropanone benzyloxime solketal iterative nucleophilic substitution; oxime ether diketal derivative preparation deprotection spiroacetalization; dioxaspiroundecane azathia derivative stereoselective preparation; azatrioxaspiroundecane derivative stereoselective preparation; thiatrioxaspiroundecane derivative stereoselective preparation.Application In Synthesis of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine.
This work describes a modular efficient route to 10-aza-4-thia-, 10-aza-4-oxa-, and 10-oxa-4-thia-1,7-dioxaspiro[5.5]undecanes. The synthetic pathway relies upon the iterative nucleophilic substitution of 1,3-dichloropropan-2-one O-benzyloxime by solketal derivatives The oxime key-intermediates, submitted to an acidic deprotection-spiroacetalization process, afforded these original spiroketal compounds in three steps, few purifications, and very good yields.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics