Extracurricular laboratory: Synthetic route of 27469-61-0

Although many compounds look similar to this compound(27469-61-0)Application of 27469-61-0, numerous studies have shown that this compound(SMILES:ClC1=CC=C(C=C1)C(N2CCNCC2)C3=CC=C(Cl)C=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Song, Kwang-Seop; Lee, Sung-Han; Chun, Hyun Ji; Kim, Jong Yup; Jung, Myung Eun; Ahn, Kwangwoo; Kim, Soo-Un; Kim, Jeongmin; Lee, Jinhwa researched the compound: 1-(Bis(4-chlorophenyl)methyl)piperazine( cas:27469-61-0 ).Application of 27469-61-0.They published the article 《Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands》 about this compound( cas:27469-61-0 ) in Bioorganic & Medicinal Chemistry. Keywords: CB1 cannabinoid antagonist piperazine preparation SAR. We’ll tell you more about this compound (cas:27469-61-0).

After the CB1 receptor antagonist SR141716 (rimonabant) was previously reported to modulate food intake, CB1 antagonism has been considered as a new therapeutic target for the treatment of obesity. Several series of urea, carbamate, amide, sulfonamide and oxalamide derivatives based on 1-benzhydrylpiperazine scaffold were synthesized and tested for CB1 receptor binding affinity. The SAR studies to optimize the CB1 binding affinity led to the potent urea derivatives After the addnl. SAR studies to optimize the substituents of di-Ph rings, the combination of 2-chlorophenyl and 4-chlorophenyl turned out to be the most potent scaffold. The CB2 binding affinity assay as well as functional assay was also conducted on these compounds Herein we wish to introduce several novel CB1 antagonists with IC50 values less than 100 nM for the CB1 receptor binding.

Although many compounds look similar to this compound(27469-61-0)Application of 27469-61-0, numerous studies have shown that this compound(SMILES:ClC1=CC=C(C=C1)C(N2CCNCC2)C3=CC=C(Cl)C=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics