Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16400-32-1, is researched, SMILESS is CCC#CCBr, Molecular C5H7BrJournal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Tandem Double-Cross-Coupling/Hydrothiolation Reaction of 2-Sulfenyl Benzimidazoles with Boronic Acids, Author is Lopes, Alexandra Basilio; Choury, Mickael; Wagner, Patrick; Gulea, Mihaela, the main research direction is sulfenyl benzimidazole boronic acid palladium catalyst regioselective stereoselective; tandem Suzuki Miyaura cross coupling hydrothiolation; substituted benzimidazole preparation.HPLC of Formula: 16400-32-1.
A new tandem palladium-catalyzed reaction involving a Suzuki-Miyaura coupling, a desulfenylative coupling, and a hydrothiolation of a triple bond is reported. Notably, the desulfenylative coupling occurs without copper(I) assistance and the hydrothiolation is totally regioselective and stereoselective. The overall process results in the double incorporation of the boronic acid and the reincorporation of the sulfenyl moiety into the product structure. Starting from 2-(bromobenzylsulfenyl)-1-propargyl benzimidazoles, the transformation led to variously substituted benzimidazoles bearing a stereodefined alkenyl sulfide.
After consulting a lot of data, we found that this compound(16400-32-1)HPLC of Formula: 16400-32-1 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics