《Ir/Ni photoredox dual catalysis with heterogeneous base enabled by an oscillatory plug flow photoreactor》 was written by Debrouwer, Wouter; Kimpe, Wim; Dangreau, Ruben; Huvaere, Kevin; Gemoets, Hannes P. L.; Mottaghi, Milad; Kuhn, Simon; Van Aken, Koen. Quality Control of 4-Bromotetrahydropyran And the article was included in Organic Process Research & Development in 2020. The article conveys some information:
Continuous flow reactor technol. has a proven track record in enabling photochem. transformations. However, transfer of a photochem. batch process to a flow protocol often remains elusive, especially when solid reagents or catalysts are employed. In this work, application of an oscillatory plug flow photoreactor enabled a heterogeneous MacMillan-type C(sp2)-C(sp3) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp2)-C(sp3) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity (0.87 g/h). After reading the article, we found that the author used 4-Bromotetrahydropyran(cas: 25637-16-5Quality Control of 4-Bromotetrahydropyran)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents, preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans; preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes.Quality Control of 4-Bromotetrahydropyran
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics