In 2017,Li, Gang; Ma, Xingxing; Jia, Chunqi; Han, Qingqing; Wang, Ya; Wang, Junjie; Yu, Liuyang; Yang, Suling published 《Ruthenium-catalyzed meta/ortho-selective C-H alkylation of azoarenes using alkyl bromides》.Chemical Communications (Cambridge, United Kingdom) published the findings.Product Details of 25637-16-5 The information in the text is summarized as follows:
Meta/ortho-selective CAr-H (di)alkylation reactions of azoarenes I (R = C6H5, 4-CH3C6H4, 4-ClC6H4, etc.; R1 = H, 4-CH3, 4-Br, etc.) have been achieved via [Ru(p-cymene)Cl2]2 catalyzed ortho-metalation using various types of alkyl bromides such as 3-bromopentane, bromocyclohexane, 2-bromo-2-methylpropane, etc. Particularly, dual meta-alkylation of azoarenes I and reduction offer an attractive strategy for the synthesis of meta-alkylanilines such as 3-(pentan-3-yl)aniline, 4-methyl-3-(pentan-3-yl)aniline, 4-bromo-3-(pentan-3-yl)aniline, etc. which are difficult to access via traditional aniline functionalization methods. After reading the article, we found that the author used 4-Bromotetrahydropyran(cas: 25637-16-5Product Details of 25637-16-5)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents, preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans; preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes.Product Details of 25637-16-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics