In 2019,Journal of the American Chemical Society included an article by Lovett, Gabrielle H.; Chen, Shuming; Xue, Xiao-Song; Houk, K. N.; MacMillan, David W. C.. Recommanded Product: 25637-16-5. The article was titled 《Open-Shell Fluorination of Alkyl Bromides: Unexpected Selectivity in a Silyl Radical-Mediated Chain Process》. The information in the text is summarized as follows:
Herein, author disclose a novel radical strategy for the fluorination of alkyl bromides via the merger of silyl radical-mediated halogen-atom abstraction and benzophenone photosensitization. Selectivity for halogen atom abstraction from alkyl bromides is observed in the presence of an electrophilic fluorinating reagent containing a weak N-F bond despite the predicted favorability for Si-F bond formation. To account for this surprising selectivity, preliminary mechanistic and computational studies were conducted, revealing that a radical chain mechanism is operative in which kinetic selectivity for Si-Br abstraction dominates due to a combination of polar effects and halogen atom polarizability in the transition state. This transition metal-free fluorination protocol tolerates a broad range of functional groups, including alcs., ketones, and aldehydes, which demonstrates the complementary nature of this strategy to existing fluorination technologies. This system has been extended to the generation of gem-difluorinated motifs, which are commonly found in medicinal agents and agrochems. The results came from multiple reactions, including the reaction of 4-Bromotetrahydropyran(cas: 25637-16-5Recommanded Product: 25637-16-5)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity; preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives; synthesis of gephyrotoxin via the Schmidt reaction.Recommanded Product: 25637-16-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics