《Multi-functional Building Blocks Compatible with Photo-redox-Mediated Alkylation for DNA-Encoded Library Synthesis》 was published in Organic Letters in 2020. These research results belong to Badir, Shorouk O.; Sim, Jaehoon; Billings, Katelyn; Csakai, Adam; Zhang, Xuange; Dong, Weizhe; Molander, Gary A.. Category: tetrahydropyran The article mentions the following:
DNA-encoded library (DEL) technol. has emerged as a novel interrogation modality for ligand discovery in the pharmaceutical industry. Given the increasing demand for a higher proportion of C(sp3)-hybridized centers in DEL platforms, a photoredox-mediated cross-coupling and defluorinative alkylation process is introduced using com. available alkyl bromides and structurally diverse α-silylamines. Notably, no protecting group strategies for amines are necessary for the incorporation of a variety of amino-acid-based organo-silanes, providing crucial branching points for further derivatization. The experimental process involved the reaction of 4-Bromotetrahydropyran(cas: 25637-16-5Category: tetrahydropyran)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity; preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives; synthesis of gephyrotoxin via the Schmidt reaction.Category: tetrahydropyran
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics