In 2017,Gu, Jun; Qiu, Canbin; Lu, Wenbin; Qian, Qun; Lin, Kunhua; Gong, Hegui published 《Nickel-Catalyzed Reductive Cross-Coupling of Vinyl Bromides with Unactivated Alkyl Halides》.Synthesis published the findings.Related Products of 25637-16-5 The information in the text is summarized as follows:
In the presence of Ni(cod)2, pyridine, and MgCl2, unactivated secondary alkyl bromides such as 4-bromo-1-tosylpiperidine underwent diastereoselective reductive coupling with alkenyl bromides such as (E)-PhCH:CHBr mediated by Zn in N,N-dimethylacetamide to yield alkenes such as (E)-4-(2-phenylethenyl)-1-tosylpiperidine in 13-90% yields. The experimental part of the paper was very detailed, including the reaction process of 4-Bromotetrahydropyran(cas: 25637-16-5Related Products of 25637-16-5)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents, preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans; preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes.Related Products of 25637-16-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics