In 2022,Liu, Hong-Chao; Gong, Xiao-Ping; Wang, Yu-Zhao; Niu, Zhi-Jie; Yue, Heng; Liu, Xue-Yuan; Liang, Yong-Min published an article in Organic Letters. The title of the article was 《Three-Component Ru-Catalyzed Regioselective Alkylarylation of Vinylarenes via Meta-Selective C(sp2)-H Bond Functionalization》.Recommanded Product: 4-Bromotetrahydropyran The author mentioned the following in the article:
A novel Ru-catalyzed regioselective alkylarylation of vinylarenes with alkyl halides and arenes was reported via meta-C(sp2)-H bond functionalization to construct 1,1-diarylalkanes I [R = n-Bu, cyclohexyl, Bn, etc.; R1 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2 = H, 2-Me, 3-F, etc.; R3 = H, 5-Me, 4-MeO, etc.] that generally show bioactivity. In this transformation, a wide spectrum of primary, secondary, and tertiary alkyl halides and electronically varied arenes was well-tolerated. This reaction was characterized by its exquisite regioselectivity of vinylarenes, unique meta-C(sp2)-H selectivity, and redox-neutral conditions. The mechanism presented was supported by radical probes and kinetic isotope effect studies. In the part of experimental materials, we found many familiar compounds, such as 4-Bromotetrahydropyran(cas: 25637-16-5Recommanded Product: 4-Bromotetrahydropyran)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents, preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans; preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes.Recommanded Product: 4-Bromotetrahydropyran
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics