《Nickel-Catalyzed anti-Markovnikov Hydroalkylation of Trifluoromethylalkenes》 was written by Zhu, Chuan; Zhang, Heng; Liu, Qian; Chen, Kai; Liu, Ze-Yao; Feng, Chao. HPLC of Formula: 25637-16-5This research focused ontrifluoropropane preparation regioselective; trifluoromethylalkene alkyl halide anti Markovnikov hydroalkylation nickel. The article conveys some information:
Transition-metal-catalyzed difunctionalization of olefins constitutes a fertile synthetic platform for rapid access to complex mols. from bulk chems. However, substrates featuring fluoroalkyl substituents are rarely employed because of facile β-fluoride elimination pathways. Herein, authors report a hydroalkylation of trifluoromethylalkenes with alkyl halides under nickel catalysis that enables the rapid construction of 1,1,1-trifluoropropane derivatives The common β-fluoride elimination pathway is suppressed by identifying a competent proton donor that favors a protonolysis process. Also, unactivated alkenes could be readily employed as the alkyl donor when using a Ni/hydrosilane catalytic system. In addition to this study using 4-Bromotetrahydropyran, there are many other studies that have used 4-Bromotetrahydropyran(cas: 25637-16-5HPLC of Formula: 25637-16-5) was used in this study.
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents, preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans; preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes.HPLC of Formula: 25637-16-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics