Recommanded Product: (2-Hydroxypropyl)-β-cyclodextrinIn 2020 ,《Advantages of the combined use of cyclodextrins and nanocarriers in drug delivery: A review》 appeared in International Journal of Pharmaceutics (Amsterdam, Netherlands). The author of the article were Mura, Paola. The article conveys some information:
A review. Complexation with cyclodextrins (CDs) has been widely and successfully used in pharmaceutical field, mainly for enhancing solubility, stability and bioavailability of a variety of drugs. However, some important drawbacks, including rapid removal from the bloodstream after in vivo administration, or possible replacement, in biol. media, of the entrapped drug moieties by other mols. with higher affinity for the CD cavity, can limit the CDs effectiveness as drug carriers. This review is focused on combined strategies simultaneously exploiting CD complexation, and loading of the complexed drug into various colloidal carriers (liposomes, niosomes, polymeric nanoparticles, lipid nanoparticles, nanoemulsions, micelles) which have been investigated as a possible means for circumventing the problems associated with both such carriers, when used sep., and join their relative benefits in a unique delivery system. Several examples of applications have been reported, to illustrate the possible advantages achievable by such a dual strategy, depending on the CD-nanocarrier combination, and mainly resulting in enhanced performance of the delivery system and improved biopharmaceutical properties and therapeutic efficacy of drugs. The major problems and/or drawbacks found in the development of such systems, as well as the (rare) case of failures in achieving the expected improvements have also been highlighted. In the experiment, the researchers used (2-Hydroxypropyl)-β-cyclodextrin(cas: 128446-35-5Recommanded Product: (2-Hydroxypropyl)-β-cyclodextrin)
(2-Hydroxypropyl)-β-cyclodextrin(cas: 128446-35-5) belongs to tetrahydropyrans. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules.Recommanded Product: (2-Hydroxypropyl)-β-cyclodextrin The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif.
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics