Shi, Yanyan’s team published research in Journal of Separation Science in 38 | CAS: 69097-99-0

Journal of Separation Science published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C18H10, Application In Synthesis of 69097-99-0.

Shi, Yanyan published the artcilePreparation of a permethylated β-cyclodextrin chiral stationary phase by one-pot hydrosilylation and immobilization at the C2 position for chiral high-performance liquid chromatography, Application In Synthesis of 69097-99-0, the publication is Journal of Separation Science (2015), 38(21), 3669-3676, database is CAplus and MEDLINE.

A novel cyclodextrin intermediate, mono-2A-allylcarbamido-2A-deoxy-permethylated β-cyclodextrin, was synthesized by reacting allylamine and newly prepared mono-2A-azido-2A-deoxy-permethylated β-cyclodextrin by the Staudinger reaction and anchored onto porous silica beads by a 1-pot hydrosilylation and immobilization procedure to afford a novel chiral stationary phase. This stationary phase acts as a new member of the previous chiral stationary phase series immobilized on the cyclodextrin C2 position. This stationary phase depicted enantiomeric separation abilities toward bicyclic and tricyclic racemates under reversed-phase conditions. The resolutions for hesperetin and naringenin achieved on the current phase reached 3.91 and 1.11, resp., much higher than the previous permethylated β-cyclodextrin with the linkage at the C6 position.

Journal of Separation Science published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C18H10, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Lai, Xiang-Hua’s team published research in Tetrahedron Letters in 45 | CAS: 69097-99-0

Tetrahedron Letters published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Quality Control of 69097-99-0.

Lai, Xiang-Hua published the artcileConvenient synthesis of mono(6A-N-allyl-amino-6A-deoxy)permethylated β-cyclodextrin: a promising chiral selector for an HPLC chiral stationary phase, Quality Control of 69097-99-0, the publication is Tetrahedron Letters (2004), 45(23), 4469-4472, database is CAplus.

Mono(6-(p-toluenesulfonyl))permethylated β-cyclodextrin, a versatile precursor for a wide variety of mono-functionalized permethyl β-cyclodextrins, has been generated successfully by the direct methylation of mono-tosylated cyclodextrin. This afforded a convenient synthesis of mono(6A-N-allyl-amino-6A-deoxy)permethylated β-cyclodextrin. Hydrosilylation of the chiral selector with (EtO)3SiH and reaction of the resultant reactive siloxane with pristine silica gel afforded a facile entry into a structurally well-defined chiral HPLC stationary phase.

Tetrahedron Letters published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Quality Control of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Lai, Xiang-Hua’s team published research in Journal of Chromatography A in 1059 | CAS: 69097-99-0

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application In Synthesis of 69097-99-0.

Lai, Xiang-Hua published the artcileEnantioseparation on mono(6A-N-allylamino-6A-deoxy)permethylated β-cyclodextrin covalently bonded silica gel, Application In Synthesis of 69097-99-0, the publication is Journal of Chromatography A (2004), 1059(1-2), 53-59, database is CAplus and MEDLINE.

A chiral selector, mono(6A-N-allylamino-6A-deoxy)permethylated β-cyclodextrin, was synthesized through a facile synthetic route and chem. immobilized onto porous silica gel via hydrosilylation to afford a cyclodextrin based chiral stationary phase MeCD-CSP. This chiral stationary phase exhibited good enantioselectivity under standard HPLC conditions. The optimal resolution of 1-(p-bromophenyl)ethanol and bromopheniramine was achieved under normal-phase conditions using a mobile phase comprising n-hexane and 2-propanol (IPA). The enantioseparation of warfarin, suprofen and flavanones under reversed-phase conditions were optimized and efficient enantioseparations for these analytes were obtained.

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Hetru, C.’s team published research in Nouveau Journal de Chimie in 7 | CAS: 27943-46-0

Nouveau Journal de Chimie published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Quality Control of 27943-46-0.

Hetru, C. published the artcileSynthesis of high specific activity (23,24)-3H4-2-deoxyecdysone, Quality Control of 27943-46-0, the publication is Nouveau Journal de Chimie (1983), 7(10), 587-91, database is CAplus.

Deoxyecdysone I (R = H) was prepared from ergosterol via alkynylation of pregnenecarboxaldehyde II with R1OCMe2CCMgBr (R1 = tetrahydro-2H-pyran-2-yl) to give cholestenynones III. Reduction of cholestenyne IV by tritium in MeOH containing Pd/C and NaNO2 gave I (R = T) with a specific activity of 108 Ci/mmole. I (R = H) has biolog. activity similar to that of ecdysone and is metabolized to ecdysone and 20-hydroxyecdysone by insects.

Nouveau Journal de Chimie published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Quality Control of 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Fujimoto, Yoshinori’s team published research in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in | CAS: 27943-46-0

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Fujimoto, Yoshinori published the artcileSteroids. XXIX. Synthesis of allenic analogs of fucosterol and desmosterol, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1975), 2302-7, database is CAplus.

Reaction of 24-oxocholesterol tetrahydropyranyl (Thp) ether with NaCCH in NH3(l) gave the 24-ethynyl alc. which was acetylated. Reduction of the acetate with LiAlH4-AlCl3 (3:1) in THF gave the fucosterol allenic analog I [R = CH2C(CHMe2):C:CH2]. Coupling of 22-tolylsulfonyloxy-23,24-bisnorchol-5-en-3β-yl Thp ether with CHCCMe2OH Thp ether followed by hydrolysis gave cholest-5-en-23-yne-3β,25-diol. Treatment of the above diol with LiAlH4-AlCl3 gave the desmosterol allenic analog I (R = CH:C:CMe2).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Bankova, V.’s team published research in Organic Mass Spectrometry in 21 | CAS: 69097-99-0

Organic Mass Spectrometry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Bankova, V. published the artcileChemical-ionization mass spectrometry with amines as reactant gases. I. Amine chemical ionization mass spectrometry of flavonoid aglycones, Synthetic Route of 69097-99-0, the publication is Organic Mass Spectrometry (1986), 21(3), 109-16, database is CAplus.

Chem. ionization mass spectrometry of 34 flavones, isoflavones, flavanones, chalcones and aurones with aliphatic amines and ammonia as reactant gases have been investigated. Some unusual ions have been obtained and are discussed. This method can be used to determine the type of flavonoid and the location of some functional groups in the mol.

Organic Mass Spectrometry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Lissi, Eduardo A.’s team published research in Free Radical Research in 30 | CAS: 69097-99-0

Free Radical Research published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, SDS of cas: 69097-99-0.

Lissi, Eduardo A. published the artcileTotal antioxidant potential of resinous exudates from Heliotropium species, and a comparison of the ABTS and DPPH methods, SDS of cas: 69097-99-0, the publication is Free Radical Research (1999), 30(6), 471-477, database is CAplus and MEDLINE.

Total reactive antioxidant potential (TRAP) of resinous exudates from Heliotropium species was evaluated by measuring the bleaching of stable free radicals. The antioxidant capacity of the resinous exudates in Trolox equivalent, evaluated from the bleaching of ABTS derived radical cations, ranged from 2.0 M (H. huascoense) to 5.2 M (H. stenophyllum), indicating a very high concentration of phenolic compounds Considerably smaller values were obtained by measuring the bleaching of DPPH radicals. The ratio between the values obtained employing ABTS derived radicals and DPPH, ranged from 37 (H. megalanthum) to 4.5 (H. chenopodiaceum variety typica). The magnitude of the difference can be considered as an indication of the relative reactivity of the antioxidants present in the exudates. Similar ratios were observed when stoichiometric coefficients were evaluated for representative purified flavonoids obtained from the resinous exudates.

Free Radical Research published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, SDS of cas: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Kitaguchi, Takashi’s team published research in Drug Metabolism & Disposition in 50 | CAS: 267244-08-6

Drug Metabolism & Disposition published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Product Details of C21H24O8.

Kitaguchi, Takashi published the artcileSimultaneous evaluation of membrane permeability and UDP-glucuronosyltransferase-mediated metabolism of food-derived compounds using human induced pluripotent stem cell-derived small intestinal epithelial cells, Product Details of C21H24O8, the publication is Drug Metabolism & Disposition (2022), 50(1), 17-23, database is CAplus and MEDLINE.

Pharmacokinetic prediction after oral ingestion is important for quant. risk assessment of food-derived compounds To evaluate the utility of human intestinal absorption prediction, we compared the membrane permeability and metabolic activities of human induced pluripotent stem cell-derived small intestinal epithelial cells (hiPSC-SIECs) with Caco-2 cells or human primary enterocytes (hPECs). We found that membrane permeability in hiPSC-SIECs had better predictivity than that in Caco-2 cells against 21 drugs with known human intestinal availability (r = 0.830 and 0.401, resp.). Membrane permeability in hiPSC-SIECs was only 0.019-0.25-fold as compared with that in Caco-2 cells for 7 in 15 food-derived compounds, primarily those that were reported to undergo glucuronidation metabolism The metabolic rates of the glucuronide conjugate were similar or higher in hiPSC-SIECs as compared with hPECs but lower in Caco-2 cells. Expression levels of UDP-glucuronosyltransferase (UGT) isoform mRNA in hiPSC-SIECs were similar or higher as compared with hPECs. Therefore, hiPSC-SIECs could be a useful tool for predicting human intestinal absorption to simultaneously evaluate membrane permeability and UGT-mediated metabolism SIGNIFICANCE STATEMENT Gastrointestinal absorption is an important step for predicting the internal exposure of food-derived compounds This research revealed that human induced pluripotent stem cell-derived small intestinal cells (hiPSC-SIECs) had better predictivity of intestinal availability than Caco-2 cells; furthermore, the metabolic rates of UDP-glucuronosyltransferase (UGT) substrates of hiPSC-SIECs were closer to those of human primary enterocytes than those of Caco-2 cells. Therefore, hiPSC-SIECs could be a useful tool for predicting human intestinal absorption to simultaneously evaluate membrane permeability and UGT-mediated metabolism

Drug Metabolism & Disposition published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Product Details of C21H24O8.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Asztemborska, Monika’s team published research in Electrophoresis in 24 | CAS: 69097-99-0

Electrophoresis published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Asztemborska, Monika published the artcileSeparation of some chiral flavanones by micellar electrokinetic chromatography, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Electrophoresis (2003), 24(15), 2527-2531, database is CAplus and MEDLINE.

Micellar electrokinetic chromatog. (MEKC) was applied for enantioseparation of selected flavanones, including naringin, hesperidin, neohesperidin, naringenin, hesperetin, pinostrobin, isosakuranetin, eriodictyol, and homoeriodictyol. γ-Cyclodextrin (γ-CD) and sodium cholate (SCh) were used as chiral modifiers inducing enantio-selectivity to the background electrolyte. From among many studied selectors only these two appeared to possess the best enantioselective properties in respect to studied flavanones. The mechanisms of their action are a little different; SCh used above critical micelle point concentration forms chiral micelles itself while γ-CD is deprived of this property and requires addition of surfactants as, e.g., sodium dodecyl sulfate. SCh enables separation of flavanone glycosides diastereomers while separation of enantiomers of flavanone aglycons may be achieved with γ-CD. Consideration of structural relation led to the suggestion that interaction of sugar moiety of glycosides with SCh micelles give rise to chiral recognition. MEKC appeared to be a suitable and efficient anal. tool to follow enantiomeric composition of flavanones.

Electrophoresis published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Bolitt, Veronique’s team published research in Tetrahedron Letters in 29 | CAS: 27943-46-0

Tetrahedron Letters published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Bolitt, Veronique published the artcileTriphenylphosphine hydrobromide: a mild and efficient catalyst for tetrahydropyranylation of tertiary alcohols, Category: tetrahydropyran, the publication is Tetrahedron Letters (1988), 29(36), 4583-6, database is CAplus.

PPh3.HBr is a convenient and highly effective catalyst for tetrahydropyranylation of tertiary alcs. with dihydropyran in CH2Cl2 at ambient temperature Thus EtMe2COH gave 92% tetrahydropyranyl ether.

Tetrahedron Letters published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics