Chen, Xiao-yang published the artcileStudy of anti-hypertensive mechanism of Morus alba & Flos Chrysanthemi based on network pharmacology and molecular docking, HPLC of Formula: 69097-99-0, the publication is Zhonghua Zhongyiyao Zazhi (2021), 36(10), 6069-6076, database is CAplus.
Objective: To study the potential mechanism of Morus alba & Flos Chrysanthemi in the treatment of hypertension based on network pharmacol., and preliminarily verify it by mol. docking technol. Methods: The effective components of Morus alba & Flos Chrysanthemi and the common targets with hypertension were obtained by network pharmacol., then GO and KEGG were enriched and analyzed by David database. The relevant results were verified by mol. simulation docking technol. Results: There were 29 active components in Folium Mori, 20 active components in Flos Chrysanthemi and 224 common target genes with hypertension. GO enrichment anal. found that Morus alba & Flos Chrysanthemi had multiple biol. functions such as enzyme binding, protein isomerization, steroid binding and transcription factor binding, and could affect multiple cellular components such as extracellular space, cytoplasm, membrane raft and cytoplasmic perinuclear region, so as to participate in drug metabolism hypoxia reaction, neg. regulation of apoptosis, lipopolysaccharide reaction, estradiol reaction and other biol. processes. KEGG enrichment anal. showed that the effective components of Morus alba & Flos Chrysanthemi could participate in tumor necrosis factor, PI3K-Akt, HIF-1 and other signal pathways, and the effective components such as artichoke were related to β1 adrenoceptor. The docking conformation of adrenoceptor β2 was better than that of antihypertensive drug metoprolol. Conclusion: Multiple active ingredients of Morus alba & Flos Chrysanthemi has a network mechanism of multi-target and multi-channel synergistic effect on hypertension, and artichoke may be the potential mol. basis of lowering blood pressure.
Zhonghua Zhongyiyao Zazhi published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, HPLC of Formula: 69097-99-0.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics