Fujimoto, Yoshinori published the artcileSteroids. XXIX. Synthesis of allenic analogs of fucosterol and desmosterol, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1975), 2302-7, database is CAplus.
Reaction of 24-oxocholesterol tetrahydropyranyl (Thp) ether with NaCCH in NH3(l) gave the 24-ethynyl alc. which was acetylated. Reduction of the acetate with LiAlH4-AlCl3 (3:1) in THF gave the fucosterol allenic analog I [R = CH2C(CHMe2):C:CH2]. Coupling of 22-tolylsulfonyloxy-23,24-bisnorchol-5-en-3β-yl Thp ether with CHCCMe2OH Thp ether followed by hydrolysis gave cholest-5-en-23-yne-3β,25-diol. Treatment of the above diol with LiAlH4-AlCl3 gave the desmosterol allenic analog I (R = CH:C:CMe2).
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics