Hauck, Zane Z. published the artcileDetermination of bisphenol A-glucuronide in human urine using ultrahigh-pressure liquid chromatography/tandem mass spectrometry, Recommanded Product: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, the publication is Rapid Communications in Mass Spectrometry (2016), 30(3), 400-406, database is CAplus and MEDLINE.
Rationale : Used widely as a plasticizer and as a monomer for plastics, bisphenol A (BPA) is under investigation as a possible endocrine disrupter. As an indication of systemic exposure, a fast and accurate assay was developed for the major BPA metabolite in human urine, BPA-monoglucuronide (BPA-G), using ultraHPLC/tandem mass spectrometry (UHPLC/MS/MS). Methods : Urine samples were prepared using solid-phase mixed-mode reversed-phase/anion-exchange extraction BPA-G was measured using UHPLC/MS/MS with an amide UHPLC column interfaced to a triple-quadrupole mass spectrometer equipped with neg. ion electrospray, collision-induced dissociation and selected reaction monitoring. [13C12]-BPA-G was used as a surrogate standard Results : By measuring the glucuronide metabolite of BPA, potential interference due to BPA contamination from containers, solvents, pipet, etc., was avoided. The standard curve had a linear regression coefficient of 0.999, and the intra- and inter-assay variations were less than 10%. The assay was validated according to FDA guidelines. Conclusions : A fast, accurate, and highly selective method for the determination of BPA-G in human urine was developed and validated using UHPLC/MS/MS. This method is suitable for assessing human exposure to BPA. Copyright © 2016 John Wiley & Sons, Ltd.
Rapid Communications in Mass Spectrometry published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Recommanded Product: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics