Journet, Michel’s team published research in Journal of Organic Chemistry in 57 | CAS: 27943-46-0

Journal of Organic Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Related Products of tetrahydropyran.

Journet, Michel published the artcileRadical cyclization of (bromomethyl)dimethylsilyl propargyl ethers. Regio-, chemo- and stereoselectivity., Related Products of tetrahydropyran, the publication is Journal of Organic Chemistry (1992), 57(11), 3085-93, database is CAplus.

Radical cyclization of (bromomethyl)dimethylsilyl propargyl ether derivatives I [R1 = R2 = Me, R3 = (CH2)nCH:CH2, n = 1,2,4, (CH2)3OTHP, Ph, SiMe3; R1 = H, R2 = R3 = Bu; R1 = R3 = H, R2 = H, Me; R1 = R2 = H, R3 = pentyl; R1 = H, R2 = Me, R3 = Ph, pentyl] is a powerful reaction with a high degree of regio-, chemo-, and stereoselectivity. Trisubstituted olefins II (R4 = H, OH, SiMe3), cyclopentene derivatives III, and diquinane system IV are obtained in good yields by a judicious choice of unsaturated substituents. Triquinane frameworks could be obtained stereoselectively from a suitable acyclic substrate of type I in a one-pot reaction. First attempts have not yet allowed us to aim at this goal due to interesting (1,5) hydrogen transfers. Moreover, intercepted, for the first time, is the α-cyclopropyl radical which is involved in the Stork-Beckwith mechanism of the 5- vs. 6-membered ring formation in the vinyl radical cyclization.

Journal of Organic Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics