Nanayakkara, N. P. Dhammika published the artcilePotential sweetening agents of plant origin. 13. An intensely sweet dihydroflavonol derivative based on a natural product lead compound, Product Details of C16H14O6, the publication is Journal of Medicinal Chemistry (1988), 31(6), 1250-3, database is CAplus and MEDLINE.
Dihydroquercetin 3-acetate [(2R,3R)-I; R = Ac, R1 = H] (II) was isolated as a sweet constituent of the young shoots of Tessaria dodoneifolia (Hook. & Arn.) Cabrera (Compositae). II and I (R = Ac, R1 = Me), a novel synthetic analog of II, were rated by a taste panel as being 80 and 400 times sweeter resp. than a 2% sucrose solution Synthetic I (R = H, R1 = Me) showed a reduced sweetness intensity compared to I (R = Ac, R1 = Me) and (+)-dihydroquercetin was devoid of sweetness. I represent a new class of potentially noncaloric and noncariogenic intense sweeteners. I (R = Ac, R1 = Me) was prepared from acetophenone and benzaldehyde components in 5 steps. I (R = H, R1 = Me) was obtained from hesperetin by ring cleavage with PhCH2Cl, epoxidation and ring closure.
Journal of Medicinal Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Product Details of C16H14O6.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics