Sun, Dianqing published the artcileEvaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead, Quality Control of 69097-99-0, the publication is ChemMedChem (2012), 7(9), 1541-1545, database is CAplus and MEDLINE.
As part of our ongoing effort to discover novel antitubercular and antibacterial agents and to exploit natural products as scaffolds for chem. diversity, we have been interested in following up emerging and underexplored naturally occurring compounds showing good antimicrobial activities. In this regard, natural phytochems. are actively being pursued for their antibacterial properties. We subsequently screened the collated flavonoid and resveratrol library against M. tuberculosis and a panel of Gram-pos. and Gram-neg. bacterial pathogens, including Enterococcus faecalis, S. aureus, S. pneumoniae, Klebsiella pneumoniae, Acine-tobacter baumannii, Escherichia co/i, and P. aeruginosa. In conclusion, the systematic screening of a focused flavonoid and resveratrol library led to the identification of abyssinone II as an anti-Gram-pos. agent that could potentially have a multitargeted mode of action, resulting from its ability to target the bacterial membrane. Such agents are increasingly becoming attractive therapeutic options owing to their potent actions, likely multitarget effects and limited potential for resistance development. The characterization of abyssinone II as a membrane-targeting mol. therefore makes it a promising natural product lead, ideal for further medicinal chem. optimization to identify advanced exptl. candidates with antimicrobial therapeutic potential.
ChemMedChem published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C65H82N2O18S2, Quality Control of 69097-99-0.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics