Martins, Francisco A.’s team published research in Beilstein Journal of Organic Chemistry in 13 | CAS: 624734-19-6

Beilstein Journal of Organic Chemistry published new progress about 624734-19-6. 624734-19-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Fluoride,Ketone, name is 3-Fluorodihydro-2H-pyran-4(3H)-one, and the molecular formula is C5H7FO2, Related Products of tetrahydropyran.

Martins, Francisco A. published the artcileConformational impact of structural modifications in 2-fluorocyclohexanone, Related Products of tetrahydropyran, the publication is Beilstein Journal of Organic Chemistry (2017), 1781-1787, database is CAplus and MEDLINE.

2-Haloketones are building blocks that combine phys., chem. and biol. features of materials and bioactive compounds, while organic fluorine plays a fundamental role in the design of performance organic mols. Since these features are dependent on the three-dimensional chem. structure of a mol., simple structural modifications can affect its conformational stability and, consequently, the corresponding physicochem./biol. property of interest. In this work, structural changes in 2-fluorocyclohexanone were theor. studied with the aim at finding intramol. interactions that induce the conformational equilibrium towards the axial or equatorial conformer. The interactions evaluated were hydrogen bonding, hyperconjugation, electrostatic and steric effects. While the gauche effect, originated from hyperconjugative interactions, does not appear to cause some preferences for the axial conformation of organofluorine heterocycles, more classical effects indeed rule the conformational equilibrium of the compounds Spectroscopic parameters (NMR chem. shifts and coupling constants), which can be useful to determine the stereochem. and the interactions operating in the series of 2-fluorocyclohexanone derivatives, were also calculated

Beilstein Journal of Organic Chemistry published new progress about 624734-19-6. 624734-19-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Fluoride,Ketone, name is 3-Fluorodihydro-2H-pyran-4(3H)-one, and the molecular formula is C5H7FO2, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Le Pham, Ngoc Son’s team published research in Journal of Organic Chemistry in 85 | CAS: 27943-46-0

Journal of Organic Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, HPLC of Formula: 27943-46-0.

Le Pham, Ngoc Son published the artcileOxidative Dehydrosulfurative Cross-Coupling of 3,4-Dihydropyrimidine-2-thiones with Alkynes for Access to 2-Alkynylpyrimidines, HPLC of Formula: 27943-46-0, the publication is Journal of Organic Chemistry (2020), 85(7), 5087-5096, database is CAplus and MEDLINE.

Dihydropyrimidinethiones such as I [R = t-Bu, Me(CH2)n, i-PrCH2CH2, PhCH2CH2, c-C6H11CH2, cyclopentyl, cyclohexyl, PhCH2O(CH2)3, THPOCMe2, Ph, 4-MeC6H4, 4-MeOC6H4, 1-naphthyl; n = 5, 7; THP = tetrahydro-2-pyranyl] underwent desulfurative Sonogashira coupling and oxidative aromatization reactions with terminal alkynes RCCH in the presence of Pd(OAc)2, 1,3-bis(diphenylphosphino)propane (dppp), copper(I) 2-thiophenecarboxylate (CuTC), and Cs2CO3 in 4:1 toluene:MeCN to yield alkynylpyrimidines such as II [R = t-Bu, Me(CH2)n, i-PrCH2CH2, PhCH2CH2, c-C6H11CH2, cyclopentyl, cyclohexyl, PhCH2O(CH2)3, THPOCMe2, Ph, 4-MeC6H4, 4-MeOC6H4, 1-naphthyl; n = 5, 7].

Journal of Organic Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, HPLC of Formula: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Pimkov, Igor V.’s team published research in Chemistry – A European Journal in 21 | CAS: 27943-46-0

Chemistry – A European Journal published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Pimkov, Igor V. published the artcileDesigning the Molybdopterin Core through Regioselective Coupling of Building Blocks, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Chemistry – A European Journal (2015), 21(47), 17057-17072, database is CAplus and MEDLINE.

2-Amino-5,6,7,8-tetrahydro-6-[3-hydroxy-1,2-dimercapto-4-(phosphonooxy)-1-buten-1-yl]-4(3H)-pteridinone (i.e. molybdopterin) is an essential cofactor for all forms of life. The cofactor is composed of a pterin moiety appended to a dithiolene-functionalized pyran ring, and through the dithiolene moiety it binds metal ions. Different synthetic strategies for dithiolene-functionalized pyran precursors that have been designed and synthesized are discussed. These precursors also harbor 1,2-diketone or osone (i.e., monosaccharide, osulose) functionality that has been condensed with 1,2-diaminobenzene or other heterocycles resulting in several quinoxaline or pterin derivatives Use of additives improves the regioselectivity of the complexes. The mols. have been characterized by 1H and 13C NMR and IR spectroscopies, as well as by mass spectrometry. In addition, several compounds have been crystallog. characterized. The geometries of the synthesized mols. are more planar than the geometry of the cofactor found in proteins. The synthesis of the target compounds was achieved using 4,4-dimethyl-2-thioxo-4H-1,3-dithiolo[4,5-c]pyran-6,7-dione, 4,4-dimethyl-4H-1,3-dithiolo[4,5-c]pyran-2,6,7-trione as key intermediates. The title compounds thus formed included 4,4-dimethyl-4H-1,3-dithiolo[4,5]pyrano[2,3-b]quinoxaline-2-thione,.

Chemistry – A European Journal published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Sharma, Raju Prasad’s team published research in Science of the Total Environment in 624 | CAS: 267244-08-6

Science of the Total Environment published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C9H4F6O, HPLC of Formula: 267244-08-6.

Sharma, Raju Prasad published the artcileThe development of a pregnancy PBPK Model for Bisphenol A and its evaluation with the available biomonitoring data, HPLC of Formula: 267244-08-6, the publication is Science of the Total Environment (2018), 55-68, database is CAplus and MEDLINE.

Recent studies suggest universal fetal exposure to Bisphenol A (BPA) and its association with the adverse birth outcomes. Estimation of the fetal plasma BPA concentration from the maternal plasma BPA would be highly useful to predict its associated risk to this specific population. The objective of current work is to develop a pregnancy-physiol. based pharmacokinetic (P-PBPK) model to predict the toxicokinetic profile of BPA in the fetus during gestational growth, and to evaluate the developed model using biomonitoring data obtained from different pregnancy cohort studies. To achieve this objective, first, the adult PBPK model was developed and validated with the human BPA toxicokinetic data. This validated human PBPK model was extended to develop a P-PBPK model, which included the physiol. changes during pregnancy and the fetus sub-model. The developed model would be able to predict the BPA pharmacokinetics (PKs) in both mother and fetus. Transplacental BPA kinetics parameters for this study were taken from the previous pregnant mice study. Both oral and dermal exposure routes were included into the model to simulate total BPA internal exposure. The impact of conjugation and deconjugation of the BPA and its metabolites on fetal PKs was investigated. The developed P-PBPK model was evaluated against the observed BPA concentrations in cord blood, fetus liver and amniotic fluid considering maternal blood concentration as an exposure source. A range of maternal exposure dose for the oral and dermal routes was estimated, so that simulation concentration matched the observed highest and lowest mother plasma concentration in different cohorts’ studies. The developed model could be used to address the concerns regarding possible adverse health effects in the fetus being exposed to BPA and might be useful in identifying critical windows of exposure during pregnancy.

Science of the Total Environment published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C9H4F6O, HPLC of Formula: 267244-08-6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Khlebnikov, Andrei I.’s team published research in Bioorganic & Medicinal Chemistry in 15 | CAS: 69097-99-0

Bioorganic & Medicinal Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, HPLC of Formula: 69097-99-0.

Khlebnikov, Andrei I. published the artcileImproved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems, HPLC of Formula: 69097-99-0, the publication is Bioorganic & Medicinal Chemistry (2007), 15(4), 1749-1770, database is CAplus and MEDLINE.

Quant. structure-activity relationship (QSAR) models are useful in understanding how chem. structure relates to the biol. activity of natural and synthetic chems. and for design of newer and better therapeutics. In the present study, 46 flavonoids and related polyphenols were evaluated for direct/indirect antioxidant activity in three different assay systems of increasing complexity (chem., enzymic, and intact phagocytes). Based on these data, two different QSAR models were developed using (i) physicochem. and structural (PC&S) descriptors to generate multiparameter partial least squares (PLS) regression equations derived from optimized mol. structures of the tested compounds and (ii) a partial 3D comparison of the 46 compounds with local fingerprints obtained from fragments of the mols. by the frontal polygon (FP) method. We obtained much higher QSAR correlation coefficients (r) for flavonoid end-point antioxidant activity in all three assay systems using the FP method (0.966, 0.948, and 0.965 for datasets evaluated in the biochem., enzymic, and whole cell assay systems, resp.). Furthermore, high leave-one-out cross-validation coefficients (q 2) of 0.907, 0.821, and 0.897 for these datasets, resp., indicated enhanced predictive ability and robustness of the model. Using the FP method, structural fragments (submols.) responsible for the end-point antioxidant activity in the three assay systems were also identified. To our knowledge, this is the first QSAR model derived for description of flavonoid direct/indirect antioxidant effects in a cellular system, and this model could form the basis for further drug development of flavonoid-like antioxidant compounds with therapeutic potential.

Bioorganic & Medicinal Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, HPLC of Formula: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Ito, Chihiro’s team published research in Phytochemistry in 28 | CAS: 69097-99-0

Phytochemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Category: tetrahydropyran.

Ito, Chihiro published the artcileTwo flavanones from Citrus species, Category: tetrahydropyran, the publication is Phytochemistry (1989), 28(12), 3562-4, database is CAplus.

The new flavanones, hiravanone (I) and yukovanol (II) were isolated from root extracts of some Citrus species and their structures were determined by spectrometric and synthetic methods.

Phytochemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Doutheau, Alain’s team published research in Synthetic Communications in 12 | CAS: 27943-46-0

Synthetic Communications published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Doutheau, Alain published the artcileSynthesis of α-functionalized allenes, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Synthetic Communications (1982), 12(7), 557-63, database is CAplus.

Propargylic compounds HCCCR2X (R = H, Me; X = tetrahydropyranyloxy, OH, NH2) were converted to the resp. allenes Me2C:C:CHCR2X in two steps. Thus, HCCCH2OH was treated with BuLi and Me2C(NO2)2, and the Me2C(NO2)CCCH2OH obtained was treated with LiAlH4 in THF to give Me2C:C:CHCH2OH.

Synthetic Communications published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Trdan Lusin, Tina’s team published research in Toxicology in 292 | CAS: 267244-08-6

Toxicology published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C12H17NO2, Name: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid.

Trdan Lusin, Tina published the artcileEvaluation of bisphenol A glucuronidation according to UGT1A1*28 polymorphism by a new LC-MS/MS assay, Name: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, the publication is Toxicology (2012), 292(1), 33-41, database is CAplus and MEDLINE.

The endocrine disruptor bisphenol A (BPA) is a frequently used chem. in the manufacture of consumer products. In humans, BPA is extensively metabolized to BPA glucuronide (BPAG) by different UDP-glucuronosyltransferase (UGT) isoforms. The study has been performed with the intention to improve the accuracy of published physiol. based pharmacokinetic models and to improve regulatory risk assessments of BPA. In order to gain insight into intestine, kidney, liver, and lung glucuronidation of BPA, human microsomes of all tested organs were used. BPAG formation followed Michaelis-Menten kinetics in the intestine and kidney, but followed substrate inhibition kinetics in the liver. Human lung microsomes did not show glucuronidation activity towards BPA. While the liver intrinsic clearance was very high (857 mL min-1 kg body weight-1), the tissue intrinsic clearances for the kidney and intestine were less than 1% of liver intrinsic clearance. Since BPA is a UGT1A1 substrate, we postulated that the common UGT1A1*28 polymorphism influences BPA glucuronidation, and consequently, BPA detoxification. Hepatic tissue intrinsic clearances for UGT1A1*1/*1, UGT1A1*1/*28, and UGT1A1*28/*28 microsomes were 1113, 1075, and 284 mL min-1 kg body weight-1, resp. Prior to microsomal experiments, the bioprodn. of BPAG and stable isotope-labeled BPAG (BPAGd16) was performed for the purpose of the reliable and accurate quantification of BPAG. In addition, a sensitive LC-MS/MS anal. method for the simultaneous determination of BPA and BPAG based on 2 stable isotope-labeled internal standards was developed and validated. In conclusion, our in vitro results show that the liver is the main site of BPA glucuronidation (K m 8.9 μM, V max 8.5 nmol min-1 mg-1) and BPA metabolism may be significantly influenced by a person’s genotype (K m 10.0-13.1 μM, V max 3.4-16.2 nmol min-1 mg-1). This discovery may be an important fact for the currently on-going worldwide BPA risk assessments and for the improvement of physiol. based pharmacokinetic models.

Toxicology published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C12H17NO2, Name: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Yanez, Jaime A.’s team published research in Biopharmaceutics & Drug Disposition in 29 | CAS: 69097-99-0

Biopharmaceutics & Drug Disposition published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C12H15NO, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Yanez, Jaime A. published the artcilePharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Biopharmaceutics & Drug Disposition (2008), 29(2), 63-82, database is CAplus and MEDLINE.

The majority of pharmacokinetic studies of individual flavonoids or after ingestion of foodstuffs have overlooked the chirality of some of these xenobiotics. In order to characterize for the first time the stereoselective pharmacokinetics of three flavonoids, hesperetin, naringenin and eriodictyol were i.v. administered (20 mg/kg) to male Sprague-Dawley rats, and their stereospecific content was assessed in various fruit juices. Concentrations in serum, urine and fruit juices were characterized via HPLC and verified by LC/MS. Short half-lives (3-7 h) in serum were observed, while a better estimation of half-life (12-48 h) and the other pharmacokinetic parameters was observed using urinary data. The three flavonoids are predominantly excreted via non-renal routes (fe values of 3-7%), and undergo rapid and extensive phase II metabolism The (2S)-epimers of the flavonoid glycosides and the S(-)-enantiomers of the aglycons were predominant and in some instances the organic fruit juices had higher concentrations than the conventional fruit juices. This study reports for the first time the stereospecific pharmacokinetics of three chiral flavonoids and their stereospecific content in fruit juices. It also reports for the first time the stereospecific pharmacokinetics of flavonoids employing urine as a more reliable biol. matrix.

Biopharmaceutics & Drug Disposition published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C12H15NO, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Ezzat, Mohammed oday’s team published research in Journal of Microbiology, Biotechnology and Food Sciences in 10 | CAS: 69097-99-0

Journal of Microbiology, Biotechnology and Food Sciences published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Computed Properties of 69097-99-0.

Ezzat, Mohammed oday published the artcileMolecular modelling design and opioid binding affinity evaluation of new 4-chromanone derivatives, Computed Properties of 69097-99-0, the publication is Journal of Microbiology, Biotechnology and Food Sciences (2021), 10(4), 531-535, database is CAplus.

The pharmacotherapy treatment of pain is an active and motivated area of investigation for treatment with free side effects. This paper presents the docking ability of twenty-five analogs of 4-Chromanone derivatives inside the crystal structure of μ opioid receptor to estimate the binding affinity of each derivative Mol. modeling design approach applied to identify the effective substation position with generation of 989 novel 4-Chromanone derivatives The final result of the most active twenty novel 4-Chromanone derivatives with docking affinity range (-9.89 to -9.34) kcal/mol were selected as promising hit ligand drugs comparing with morphine docking affinity at (-6.02) kcal/mol.

Journal of Microbiology, Biotechnology and Food Sciences published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Computed Properties of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics