Mistry, Bhupendra published the artcileAccess to the substituted benzyl-1,2,3-triazolyl hesperetin derivatives expressing antioxidant and anticancer effects, Computed Properties of 69097-99-0, the publication is Arabian Journal of Chemistry (2017), 10(2), 157-166, database is CAplus.
Flavanone hesperetin based Ph substituted 1,2,3-triazolyls I [R = 4-F, 2-Me, 3-Cl, etc.] was synthesized as semi-synthetic natural product derivatives by azide-alkyne cycloaddition of propargyl-hesperetin and benzyl azides, utilizing copper-catalyzed click chem. All synthesized compounds I were analyzed for their in vitro antioxidant abilities using DPPH and ABTS bioassay. Moreover, cancerous cell inhibitory prospect of titled compounds was screened against cervical cancer cell lines, HeLa and CaSki and an ovarian cancer cell line SK-OV-3 implementing SRB assay. Bearable toxicity of compounds I was examined employing Madin-Darby canine kidney (MDCK) non-cancer cell line. An analog I [R = 3-OMe] showed most potent radical scavenging activity, whereas scaffolds I [R = 4-F, 2-Me, 3-OMe] with performed excellently in inhibiting both the cervical cancer cell lines and analog I [R = 3-CF3] expressed excellent sensitivity toward ovarian cancer cell line. From the structure-activity point of view, nature and position of the electron withdrawing and electron donating functional groups on the Ph ring attached to the triazole core may contribute to the anticipated antioxidant and anticancer action.
Arabian Journal of Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Computed Properties of 69097-99-0.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics